AI systems are solving real-world challenges and transforming industries, but there are serious concerns about how responsibly they operate on behalf of the humans that rely on them. Many ethical principles and guidelines have been proposed for AI systems, but they're often too 'high-level' to be translated into practice. Conversely, AI/ML researchers often focus on algorithmic solutions that are too 'low-level' to adequately address ethics and responsibility. In this timely, practical guide, pioneering AI practitioners bridge these gaps. The authors illuminate issues of AI responsibility across the entire system lifecycle and all system components, offer concrete and actionable guidance for addressing them, and demonstrate these approaches in three detailed case studies.